Apple juice has a positive effect on the mood states of people who suffer from Alzheimer's disease (AD). During the American study, 21 institutionalised AD patients consumed two 120ml glasses of apple juice a day for a month. Although participants demonstrated no change in dementia rating scale, caregivers reported a 27% improvement in behavioral and psychotic symptoms associated with dementia, with the largest changes in anxiety, agitation, and delusion. The authors suggest that apple juice may be a useful supplement to pharmacological approaches for attenuating the decline in mood that accompanies progression of AD, which may also reduce caregiver burden. (Apple juice improved behavioral but not cognitive symptoms in moderate-to-late stage Alzheimer's disease in an open-label pilot study. Am J Alzheimers Dis Other Demen. 2010 Jun;25(4):367-71).